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  Product  Endothelin 1, human
  HiLyte Fluor™ 488 - labeledHiLyte Fluor™ 488 - CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1 - 15 and 3 - 11)
  CAS  bovine, human, porcineBiotin - HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
  Size  0.25 mg
  Catalog #  64817-025
  US$  413
  Hits  

Purity % Peak Area By HPLC 95%
Description

This is a fluorescent (HiLyte Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.

Storage -20C
References Yanagisawa, M. et al. Nature 332, 411 (1988).
Molecular Weight 2848.4
Sequence
(One-Letter Code)
HiLyte Fluor™ 488-CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
HiLyte Fluor™ 488 - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide Bridge: 1 - 15 and 3 - 11)


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