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| Product | LL - 37, Antimicrobial Peptide, humanLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
| | CAS | Biotin - YVAD - CMK | | Size | 1 mg | | Catalog # | 61302 | | US$ | 170 | | Hits | |
| Purity |
% Peak Area By HPLC ≥ 95% |
| Description |
Antimicrobial peptide LL-37, belonging to the cathelicidin family, is the first amphipathic alpha-helical peptide isolated from human. It plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells , LL-37 is significantly resistant to proteolytic degradation in solution. |
| Detailed Information |
 Datasheet |
| Storage |
-20°C |
| References |
Dürr, UHN. et al. Biochim. Biophys. Acta 1758, 1408 (2006); Neville, F. et al. Biophys. J. 90, 1275 (2006); Oren, Z. et al. Biochem. J. 341, 501(1999). |
| Molecular Weight |
4493.3 |
Sequence
(One-Letter Code) |
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
Sequence
(Three-Letter Code) |
H - Leu - Leu - Gly - Asp - Phe - Phe - Arg - Lys - Ser - Lys - Glu - Lys - Ile - Gly - Lys - Glu - Phe - Lys - Arg - Ile - Val - Gln - Arg - Ile - Lys - Asp - Phe - Leu - Arg - Asn - Leu - Val - Pro - Arg - Thr - Glu - Ser - OH |
| Product Citations |
Cullen, TW. et al. Infect Immun 81, 430 (2013).
Henningham, A. et al. mBio 4, e00509 (2013).
Moffatt, JH. et al. Infect Immun 81, 684 (2013).
Okumura, CYM. et al. mBio 4, e00499 (2013).
Stover, E. et al. J Amer Soc Hort Sci 138. 142 (2013).
Taneja, NK. et al. J Bacteriol 195, 5102 (2013).
Gilmore, SA. et al. ACS Chem Biol 7, 863. doi: 10.1021/cb200311s (2012).
Hocquellet, A. et al. Peptides 36, 303 (2012).
Love, JF. et al. mBio 3 doi: 10.1128/mBio.00394-12 (2012).
McQuade, R. et al. Anaerobe 286, 18890. doi: 10.1074/jbc.M110.206110 (2012).
Richards, SM. et al. Front Cell Infect Microbiol 2, 102. doi: 10.3389/fcimb.2012.00102 (2012).
Strandberg, KL. et al. Infect Immun doi: 10.1128/IAI.00672-12 (2012).
Sun, Y. et al. J Bacteriol 194, 5274. doi: 10.1128/JB.00045-12 (2012).
Vega, LA. et al. Mol Microbiol 85, 1119. doi: 10.1111/j.1365-2958.2012.08163.x (2012).
Wu, W. et al. Leukemia 26, 736. doi: 10.1038/leu.2011.252 (2012).
Campbell, GR. and SA. Spector JBC 286, 18890. doi: 10.1074/jbc.M110.206110 (2011).
Dean, SN. et al. Front Microbiol 2, 128. doi: 10.3389/fmicb.2011.00128 (2011).
Lebeer, S. et al. Microbial Biotech 4, 368 (2011).
McBride, SM. et al. Microbiol 157, 1457. doi: 10.1099/mic.0.045997-0 (2011).
Sakoulas, G. et al. Antimicrob Agents Chemother 56, 838. doi: 10.1128/AAC.05551-11 (2011).
Sochacki, KA. et al. PNAS 108, E77. doi: 10.1073/pnas.1101130108 (2011).
Subramanian, H. et al. JBC 286, 44739. doi: 10.1074/jbc.M111.277152 (2011).
Amer, L. et al. BBRC 396, 246 (2010).
Cole, JN. et al. mBio 1 doi: 10.1128/mBio.00191-10 (2010).
Gable, JE. et al. Biochem 48, 11264. doi: 10.1021/bi900996q (2009).
Inomata, KA. et al. Eur J Oral Sci 118, 574. doi: 10.1111/j.1600-0722.2010.00775.x (2010).
Into, T. Cell Immunol 264, 104 (2010).
Kanda, N. et al. Hum Immunol 71, 1161 (2010).
Krasnodembskaya, A. et al. Stem Cells doi: 10.1002/stem.544 (2010).
Hocquellet, A. et al. Peptides 155, 2818 (2009).
Kooi, C & PA Sokol, Microbiology 155, 2818 (2009).
Yin, J & FS Yu, ARVO 10.1167/iovs.09-3904 (2009).
Purdy, GE. et al. Mol Microbiol 73, 844. doi: 10.1111/j.1365-2958.2009.06801.x (2009).
Schlamadinger, DE. et al. SPIE Proceedings 7397 doi: 10.1117/12.827439 (2009).
Lee, HM. et al. Leukemia 23, 2052. doi:10.1038/leu.2009.158 (2009).
Bourbon, C. et al. Anal Biochem 381, 279 (2008). |
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