Beta - Amyloid (1 - 42) - 成都凯捷生物医药科技发展有限公司

Catalog Products

ADP-Ribosylation Factors (ARF)

Adrenomedullin Peptides

Agouti Related Peptides

Amylin Peptides

Amyloid Peptides

Angiotensins and Related Peptides

Annexin

Anti-Inflammatory Peptides

Antimicrobial and Related Peptides

Antioxidant Peptides

Apelin Peptides

Apolipoprotein Peptides

Apoptosis Peptides

Arg-Phe-Amide RFamide Related Peptides

Bacterial Peptides

Basic Fibroblast Growth Factor (bFGF)

Bcl / BAD Peptides

Bombesins

Bradykinins

C-Peptides

C3a Peptides

Calcitonin Related Peptides

Cancer Research Peptides

Cardiac Peptides

CART (Cocaine- and Amphetamine-Regulated Transcript) Peptides

Casomorphin Peptides

Caspase Related Peptides

CEF Control Peptides

Cell Adhesion Peptides

Cell Permeable Peptides (CPP) / Drug Delivery Peptides

Chemotaxis Peptides

Cholecystokinin-Pancreozymin Peptides

ClearPoint™-Heavy Isotope Labeled and Related Peptides

Corticotropin Related Peptides

Cyclic Peptides

Cytochromes and Related Peptides

Defensins

Deltorphin Peptides

Dynorphin Peptides

Endorphin Peptides

Endothelins

Enkephalins

Enzyme Substrates and Inhibitors

Exendins

Extracellular Matrix

Fibrinogen and Related Peptides

Fibronectin Fragments

Fluorescent Labeled Peptides

FRET Peptides

Galanins

Gastric Inhibitory Peptides (GIPs)

Gastrins

Ghrelins and Obestatins

Glucagon-Like Peptides

Glycopeptides

GPCR Peptide Ligands

Growth Factors

Growth Hormone Related Peptides

Hepatitis C Virus (HCV) Related Peptides

Histones

Guanylins

HIV Related Peptides

Hydrocarbon-Stapled Peptides

Integrins

Ion Channel Peptides

Kinases/Phosphatase Substrates

Luteinizing Hormone-Releasing Hormones and Related Peptides

MAPS Peptides

Matrix Metalloproteinases (MMPs)

Melan-A and Mucin Related Peptides

Melanocyte Stimulating Hormones and Analogs

MHC related

Microbial Peptides

Milk Peptides

Myelin Oligodendrocyte Glycoprotein (MOG)/Myelin Basic Proteins (MBP)

Myosin

Natriuretic Peptides

Neurokinins

Neuromedins

Neuropeptide Y and Analogs

Neuropeptides

Neurotensins and Related Peptides

NF-kB/Transcription Factors Related Peptides

Opioid Related Peptides

Orexins

Osteocalcin Fragments

OVA Peptides

Oxytocins, Vasopressins, and Related Peptides

p53 Peptides

Pancreatic Polypeptides

Parathyroid Hormones and Related Peptides

Peptide Aminoluciferin Custom Synthesis For Bioluminescent Assays

Peptide Standards

Peptide YY and Analogs

Peptidoglycan Peptides

Phagocytosis

Phosphopeptides

Phytochelatins

Pituitary Adenylate Cyclase Activating Peptides (PACAPS)

Prion Protein (PrP) Fragments

Prolactin Releasing Peptides

Protease Inhibitors

Protein Phosphorylation Related Peptides

Proteolipid Proteins (PLPs)

QA-GSH

Renin

Retinoid Binding Protein

RGD Peptides

Saposin Related Peptides

Secretins

Selectin Related Peptides

Signal Transduction Peptides

Somatostatins

Substance P and Analogs

Tag Peptides

Tau Peptides

Temporins

Thrombin Related Peptides

Thrombospondins

Thyrotropin Releasing Hormones and Related Peptides

Toxins

Tubulin Peptides

Urotensin related peptides

Vasoactive Intestinal Peptides (VIPs)

Viral Peptides

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Product	Beta - Amyloid (1 - 42) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
CAS	A21G Flemish MutationDAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVVIA
Size	1 mg
Catalog #	20276
US$	280
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Purity	% Peak Area By HPLC ≥ 95%
Description	Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS) Brochure
Storage	-20°C
References	Ref: Nagele, R. et al. Neurosci. 110, 199 (2002); Garzon-Rodriguez, W. et al. J. Biol. Chem. 272, 21037 (1997).
Molecular Weight	4514.1
Sequence (One-Letter Code)	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence (Three-Letter Code)	H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH
Product Citations	Zhang, QG. et al. (2013). Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain 136, 1432. doi: 10.1093/brain/awt046. Chen, J. et al. (2012). Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. Plos One doi:10.1371/journal.pone.0033177 Orlando, RA. et al. (2012). A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization. Plos One doi:10.1371/journal.pone.0031869 Takata, K. et al. (2012). Microglial amyloid-β1-40 phagocytosis dysfunction is caused by high-mobility group box protein-1: Implications for the pathological progression of Alzheimer’s Disease. Intl J Alz Dis doi:10.1155/2012/685739 Davis, RC. et al. (2011). Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Mol Neurodegener 6, 10. Dillen, L. et al. (2011). A screening UHPLC–MS/MS method for the analysis of amyloid peptides in cerebrospinal fluid of preclinical species. Bioanalysis 3, 45. Li, W. et al. (2011). Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein. Brain Res doi: 10.1016/j.brainres.2011.02.078. Li, YP. et al. (2011). Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur J Med Chem 46, 1472. Libeu, CP. et al. (2011). Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimer's Dis 25, 547. Pandya, A. et al. (2011). Allosteric modulator desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-Amyloid1–42 peptide. J Mol Neurosci doi: 10.1007/s12031-011-9509-3. Qu, J. et al. (2011) S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide. PNAS 108, 14330 (2011). doi: 10.1073/pnas.1105172108 Wu, J. et al. (2011). Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo. Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2011.04.013. Yin, F. et al. (2011). Silibinin: A novel inhibitor of Aβ aggregation. Neurochem Int 58, 399. Spuch, C. et al. (2010). A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. Neurotox Res 17, 421. Aksenov, M. et al. (2010). HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures. Neurosci Lett 475, 174. Helmond, Z. et al. (2010). Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease. Brain Patho 20, 787. Nagano, T. et al. (2010). Prostaglandin E2 reduces amyloid β-induced phagocytosis in cultured rat microglia. Brain Res 1323, 11. Ravindran, C. et al. (2010). CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. Cell Immunol 260, 113. Reza, M. et al. (2010). Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer’s disease. Anal Chem 82, 7611. Ryan, D. et al. (2010). An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J Neurosci Meth 190, 171. Storace, D. et al. (2010). Elevation of β-amyloid 1-42 autoantibodies in the blood of amnestic patients with mild cognitive impairment. Arch Neurol 67, 867. Tian, G. et al. (2010) Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease. J Neurochem 113, 978. Tran, T. et al. (2010) Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease. Neurobiol Disease 37, 756. Tran, T. et al. (2010). Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease. Hippocampus 10.1002/hipo.20790. Vargas, T. et al. (2010). Gelsolin restores Aβ-induced alterations in choroid plexus epithelium. J Biomed Biotech doi: 10.1155/2010/805405. Wang, Y. et al. (2010). Two-Photon and Time-Resolved Fluorescence Conformational Studies of Aggregation in Amyloid Peptides. J Phys Chem B 114, 7112. Wirths, O. et al. (2010). Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases. J Neural Transmission 117, 85. Arriagada, C. et al. (2009). Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Neuro Lett 470, 81. Giliberto, L. et al. (2009). Mutant presenilin 1 increases the expression and activity of BACE1. J Biol Chem 284, 9027. Gu, Z. et al. (2009). β-amyloid impairs AMPA receptor trafficking and function by reducting Ca2+/calmodulin-dependent protein kinase II synaptic distribution. J Biol Chem 284, 10639. Guix, FX. et al. (2009). Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain 132, 1335. Li, M. et al. (2009). Amyloid β interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier. J Immunol 182, 5778. Zhao, L. et al. (2009). Macrophage-mediated degradation of β-amyloid via an apolipoprotein E isoform-dependent mechanism. J Neurosci 29, 3603. Jimenez, S. et al. (2008). Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci 28, 11650. Gevorkian, G. et al. (2008). Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B). Neurochem Int 52, 1030. Solorzano-Vargas, R.S. et al. (2008). Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Mol Immunol 45, 881. Watanabe, T. et al. (2008). Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats. J Pharmacol Sci 106, 84. Chafekar, SM. et al. (2007). Aβ 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid Redox Signaling 9, 2245. Nelson, TJ. et al. (2007). Protection against beta-amyloid induced apoptosis by peptides interacting with beta-amyloid. J Biol Chem 10.1074/jbc.M705558200. Gevorkian, G. et al. (2006). Amyloid-β peptide binds to microtuble-associated protein 1B (MAP1B). Neurochem Int 52, 1030. Guo, J-P. et al. (2006). Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. PNAS 103, 1953. Shaked, GM. et al. (2006). Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP597-624). FASEB J 20, 1254. Osada, Y. et al. (2005). CLAC binds to amyloid β peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280, 8596. Piccini, A. et al. (2005). β-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem 280, 34186. Seidler, N. et al. (2005). Aβ-polyacrolein aggregates: Novel mechanism of plastic formation in senile plaques Biochem Biophys Res Communications. 335, 501. Boyd-Kimball, D. et al. (2004). Role of phenylalanine 20 in Alzheimer's amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity. Chem Res Toxicol 17, 1743. Legleiter, J. et al. (2004). Effect of different anti-Aβ antibodies on Aβ fibrillogenesis as assessed by atomic force microscopy. J Mol Biol 335, 997. Bard, Frederique, et al. (2003). Epitope and isotope specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology. PNAS 100, 2023. Takata, K. et al. (2003). Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis. Biochem Biophys Res Commun 301, 699. Uryu, S. et al. (2003). β-amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages. Biochem Biophys Res Commun 303K, 302. Kanski, J. et al. (2002). The hydrophobic environment of Met35 of Alzheimer's Aβ(1-42) is important for the neurotoxic and oxdidative properties of the peptides. Neurotox Res doi: 10.1080/10298420290023945. Barger, SW. et al. (2001). Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem 76, 846. Yao, Z-X. et al. (2001). The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cel death by inhibiting the formation of β-derived diffusible neurotoxic ligands. Brain Res 889, 181. Liang, J. et al. (2000). Interaction between β-amyloid and lens aB-crystallin. FEBS Lett 484, 98. Yatin, SM. et al. (2000). Vitamin E prevents Alzheimer's amyloid β-peptide (1-42)-induced neuronal protein oxidation and reactive oxygen species production. J Alzheimer's Dis 2, 123. Yao, Z-X. et al. (1999). Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death. Brain Res 847, 203. Yatin, SM. et al. (1999). Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett 263, 17. Bradt, BM. et al. (1998). Complement-dependent proinflammatory properties of the Alzheimer's disease β-peptide. J Exp Med 188, 431.