 Catalog Products |
|
| β-Amino Acids | | | Aliphatic Amino Acids | | | Analogs of Alanine, Glycine, Valine, and Leucine | | | Analogs of Arginine and Lysine | | | Analogs of Aspartic and Glutamic Acids | | | Analogs of Benzoic Acid | | | Analogs of Cysteine and Methionine | | | Analogs of Phenylalanine and Tyrosine | | | Analogs of Proline | | | Analogs of Serine, Threonine, and Statine | | | Analogs of Tryptophan | | | Aromatic Amino Acids | | | Azide and Alkyne containing Amino Acids | | | Building Blocks for Stapled Peptides | | | Depsipeptides | | | Dye-labeled Amino Acids | | | Heterocyclic Amino Acids | | | N-α-Methyl Amino Acids | | | PEGylated Amino Acids | | | PTM Building Blocks | |
|
 |
| Product | Azidohomoalanine
| | CAS | | | Size | 100 mg | | Catalog # | 63669 | | US$ | 545 | | Hits | |
| Description |
An unusual amino acid used in Solid Phase Peptide Synthesis (SPPS) for the synthesis of modifiable side-chain peptides and proteins.1 The side-chain azido (N3) group is stable in trifluoroacetic acid (TFA) and piperidine (Pip), two reagents commonly used in SPPS. The azido group can be readily converted to an amine on the solid phase or in solution via the Staudinger reduction.2 In addition, incorporation of azidohomoalanine into proteins has shown promise as an effective IR probe into local electrostatic environments of proteins.3
|
| Detailed Information |
 Material Safety Data Sheets (MSDS)
 Catalog
 Flyer |
| Storage |
-20°C Protected from Light |
| References |
1. Vallee, M. R. J.; Majkut, P.; Wilkening, C. W.; Muller, G.; Hackenberger, C. P. R. Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins.Org. Lett. 2011 (13) 5440-5443.
2. Staudinger, H.; Meyer, J. UberneueorganischePhosphorverbindungen III. Phosphinmethylenederivative und Phosphinimine. Helvetica Chim. Acta.1919 (2) 635-646.
3. Oh, K.-I.; Lee, J.-H.; Joo, C.; Han, H.; Cho, M. β-Azidoalanine as an IR Probe: Application to Amyloid A β (16-22) Aggregation. J. Phys. Chem. B.2008 (112) 10352-10357. |
| Molecular Weight |
144.1 |
| Molecular Formula |
C4H8N4O2 |
| Product Citations |
Deal, R. et al. (2010). Genome-Wide Kinetics of Nucleosome Turnover Determined by Metabolic Labeling of Histones. Science 328, 1161. |
|
|
